GENEVA — The World Health Organization on Friday launched a coordinated international research initiative on the Andes virus involving 21 countries, following a recent hantavirus outbreak linked to a cruise ship.
The initiative, known as NAVIS, is a natural history study designed to improve understanding of Andes virus (ANDV) transmission dynamics, incubation periods and clinical progression. It builds on the response to the outbreak aboard the MV Hondius, which was reported to WHO in early May 2026.
The study aims to gather data from individuals exposed to the virus through various routes, including potential human-to-human transmission, which is a noted feature of Andes virus among hantaviruses. Implementation began rapidly after the cruise ship cluster, demonstrating activation of pre-existing research preparedness networks under WHO’s R&D Blueprint for pathogen families.
The outbreak on the Dutch-flagged vessel involved cases of hantavirus pulmonary syndrome. As of late May, WHO had reported around 11 laboratory-confirmed cases and two probable cases associated with the ship, including some deaths, according to official updates. The virus is endemic to parts of South America.
Sylvie Briand, WHO Chief Scientist, highlighted the importance of the effort. “Future outbreak responses should begin by activating research systems that already exist rather than trying to build them during crises,” she said in a statement.
The NAVIS platform uses protocols aligned with the International Severe Acute Respiratory and Emerging Infection Consortium (ISARIC) and connects investigators across multiple continents. It focuses on key scientific priorities identified through consultations involving more than 1,600 experts.
Andes virus can cause severe respiratory illness with a notable case fatality rate in previous outbreaks. The current initiative seeks to address gaps in knowledge about its behavior, particularly in the context of international travel. Officials from participating countries, including those affected by the cruise ship cases, are contributing data and resources.
WHO and partners continue monitoring the situation from the May outbreak. Global risk remains assessed as low outside of direct exposures, according to public health authorities. Contact tracing and follow-up for passengers and crew have been ongoing across multiple countries.
As of Saturday, the NAVIS study is in the early stages of implementation. Further details on enrollment, timelines for initial findings and participation from specific institutions were not fully detailed in initial announcements. WHO said the effort represents a model for rapid research coordination during health emergencies.
